肝硬化患者的甲状腺特征-与疾病严重程度的相关性和临床实践的建议:一个横截面的观察性研究
Sagar Prakash Sangole1, Kaustubh Salagre2
1Senior Resident, Department of General Medicine, All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India, Corresponding Author.
The Journal of the Association of Physicians of India
|September 18, 2024
概括
甲状腺异常在印度肝硬化患者中很常见. 低自由T3 (FT3) 综合征很普遍,特别是在严重的疾病中,建议进行常规甲状腺查,以更好地管理肝脏疾病.
科学领域:
- 内分泌学和肝病学 在内分泌学和肝病学.
- 研究甲状腺激素调节和肝功能之间的复杂关系.
背景情况:
- 肝脏疾病在印度是一个重大的公共卫生挑战.
- 甲状腺激素水平正在探索,以评估肝脏疾病的严重程度和预后.
- 在一家三级护理医院进行了一项观察性横截面研究.
研究的目的:
- 为了调查甲状腺异常在肝硬化患者的患病率.
- 评估甲状腺激素水平与肝脏疾病严重程度之间的相关性.
主要方法:
- 包括89名 (≥12岁) 患有超声波诊断肝硬化症的患者.
- 不包括孕妇和服用甲状腺改变药物的妇女.
- 评估了甲状腺功能测试 (FT3,FT4,TSH) 并与儿童普赫 (CP) 和MELD分数相关联.
主要成果:
- 甲状腺异常的患病率为87.6%,主要是低自由T3 (FT3) 综合征和亚临床甲状腺功能低下症.
- 低FT3综合征在晚期肝病 (CP类C) 中尤为普遍.
- FT3水平与肝病严重程度有显著的负相关性 (p=0.001).
结论:
- 甲状腺功能障碍在肝硬化患者中很常见.
- 建议进行常规的甲状腺功能测试,以便在肝硬化时早期检测和干预.
- 需要进一步研究更大的样本大小和先进的诊断方法.
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