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Updated: Jun 12, 2025

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一系列共价,细胞活性Bfl-1抑制剂的基于结构的优化

Simon C C Lucas1, J Henry Blackwell1, Ulf Börjesson2

  • 1Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

Journal of medicinal chemistry
|September 18, 2024
PubMed
概括

研究人员开发了一种针对Bfl-1的新型共价抑制剂,该蛋白质与癌症存活率和耐药性有关. 这种优化的化合物显示出显著的功效和有希望的体内疗效,用于癌症治疗.

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