脂质纳米颗粒用于增强口服生物利用性
Anushareddy Gangavarapu1, Lillian V Tapia-Lopez2, Barnali Sarkar2
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS 38677, USA. bsnabi@olemiss.edu.
Nanoscale
|September 18, 2024
概括
脂质纳米颗粒 (LNP) 增强口服药物输送,使药物吸收不良. 这些多功能系统通过克服胃肠道挑战和利用淋巴管道来提高生物可用性.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 脂质纳米颗粒 (LNP) 正在成为生物制药分类系统 (BCS) 第二类和第四类药物的有希望的药物递送系统.
- 这些药物通常由于降解和低透性而表现出不良的口服吸收和生物可用性.
- 包括固体脂质纳米粒子 (SLN) 和纳米结构脂质载体 (NLC) 在内的LNP通过封装各种类型的药物来提供解决方案.
研究的目的:
- 提供关于脂质纳米颗粒 (LNPs) 的最新信息,以增强口服药物透性差的生物可用性.
- 突出LNP通过哪些机制来改善跨胃肠道屏障的药物吸收.
- 讨论目前的挑战和基于LNP的口服药物输送的未来方向.
主要方法:
- 关于脂质纳米粒子配方及其在口服药物输送中的应用的最新文献的综述.
- 分析LNP机制,包括胃肠道过境,跨膜吸收和运输动力学.
- 在LNP设计和评估中使用的计算工具的探索.
主要成果:
- 脂质纳米粒子在增加BCSII和IV类药物的生物可用性方面具有显著的潜力.
- 临床药物利用独特的脂质特性 (生物降解性,生物相容性) 和运输途径来增强药物吸收.
- 选择性淋巴运输通路有助于通过LNP改善药物的生物可用性.
结论:
- 脂质纳米颗粒为改善具有挑战性的化合物的口服药物输送提供了一个多功能平台.
- 了解跨胃肠道障碍的LNP机制对于优化药物输送至关重要.
- 对LNP障碍和未来前景的进一步研究对于推进口服药物递送系统至关重要.
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