气管支柱肌在患有原发性纤维动力障碍的儿童中很常见 - - 一个案例笔记综述
Synne S Kennelly1,2,3, Vegard Hovland1, Iren Lindbak Matthews1
1Paediatric Department of Allergy and Lung Diseases, Oslo University Hospital, Oslo, Norway.
Pediatric pulmonology
|September 18, 2024
概括
气管支柱肌 (TBM) 常见于患有原发性纤维动力障碍 (PCD) 的儿童. 这项研究发现这些患者的TBM患病率很高,这表明它.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 遗传学 遗传学 是一个
背景情况:
- 气管支柱肌 (TBM) 影响大约2100个儿童中的1个.
- 胸内气道疾病在患有慢性肺部疾病如囊性纤维化 (CF) 的儿科患者中更为普遍,可能增加患病率.
研究的目的:
- 在被诊断患有原发性纤维功能障碍 (PCD) 的患者中确定气管 (TM),TBM和支气管 (BM) 的患病率.
- 评估PCD群体中与这些气道形相关的临床特征.
主要方法:
- 在奥斯陆大学医院,对2000年至2021年间被诊断患有PCD的儿童的医疗记录进行了回顾性审查.
- 纳入标准需要灵活光纤支气管镜 (FB) 进行TBM评估.
- 收集的数据包括人口统计数据,呼吸道症状,PCD诊断细节,支气管镜检查指标,阿特莱克塔斯存在,微生物学和FB发现.
主要成果:
- 在患有PCD的71名儿童中,32人接受了FB. 22名儿童 (69%) 呈现出胸内呼吸道不良.
- 患病率包括:孤立的TM (13%),TBM (22%),和孤立的BM (34%),其中有一些病例是叶状支气管支气管和相关的.
- 与支气管镜检查相关的并发症发生在41%的患者 (1大,12小).
结论:
- 在接受灵活光纤支气管支气管镜检查的PCD儿童中发现了TBM的显著患病率.
- 在儿科PCD患者中,TBM可能是相当大的并发症,影响临床管理策略.
相关概念视频
Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
Cystic Fibrosis: Management
145
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
145
The Bronchial Tree
2.2K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
2.2K
Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
Pulmonary Cycle: Exhalation
1.5K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.5K


