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稳定后发烧与初始肝细胞癌的预后之间的关系:15年多中心,回顾性队列研究

Qian Cai¹, Chuan Pang¹, Zhen Wang¹

¹Senior Department of Oncology, Department of Interventional Ultrasound, The Fifth Medical Center of PLA General Hospital, Beijing, People's Republic of China.

International journal of surgery (London, England)

|September 18, 2024

概括

肝癌微波切除后过渡性轻度发烧可能会防止早期复发. 这种发烧与较高的淋巴细胞计数和肝细胞癌患者的改善生存结果有关.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
医疗成像医学成像

背景情况:

发烧是肝细胞癌 (HCC) 热除的常见副作用.
在HCC患者中,切除后发烧的预后影响尚不清楚.
了解发烧的作用可以优化治疗策略.

研究的目的:

为了研究在HCC患者的脱落后发烧和预后之间的关联.
为了确定发烧特征 (短暂的低级别与长期/高级别) 是否会影响复发和存活率.
探索潜在的免疫机制,将发烧与结果联系起来.

主要方法:

对1458名接受美国指导的皮肤微波切除治疗的HCC患者进行了回顾性分析.
患者分为无发烧,短暂低度发烧 (TLF) 和长期或高度发烧 (PHF) 组.
评估结果:非常早期复发 (VER),早期复发 (ER),无病生存期 (DFS) 和整体生存期 (OS).

主要成果:

与无发烧患者相比,TLF患者的VER和ER率明显较低.
TLF与更高的DFS和5年OS率有关.
与无发烧患者相比,PHF在复发或生存方面没有显著差异.
在切除后,TLF组的淋巴细胞数量增加.

结论:

在HCC微波切除后的过渡性轻度发烧与早期复发的风险降低有关.
这种保护作用可能通过短时间的淋巴细胞激活来介导.
发烧模式为接受切除的HCC患者提供预后信息.

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