由SARS-CoV-2引起的神经并发症
Zehan Pang1, Ao Tang1, Yujie He1
1College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Clinical microbiology reviews
|September 18, 2024
概括
感染SARS-CoV-2可以导致严重的神经并发症,影响中枢神经系统和外围神经系统. 本综述详细介绍了这些情况,它们的机制以及COVID-19患者的管理策略.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 众所周知,SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 会导致呼吸系统疾病,但也会带来各种神经系统并发症.
- 超过30%的COVID-19患者出现神经症状,这表明呼吸系统以外的显著影响.
- 新出现的证据证实,SARS-CoV-2可以影响中枢神经系统 (CNS) 和外周神经系统 (PNS).
研究的目的:
- 审查和总结与SARS-CoV-2感染相关的中枢神经系统 (CNS) 并发症.
- 描述与SARS-CoV-2相关的周围神经系统 (PNS) 疾病.
- 讨论驱动这些神经疾病的机制,并提供长期COVID-19症状和管理的概述.
主要方法:
- 关于SARS-CoV-2和神经系统并发症的研究文献综述.
- 对病毒引起的中枢神经系统和神经系统疾病的发现综合.
- 讨论拟议的病理生理机制和治疗建议.
主要成果:
- 中枢神经系统的并发症包括脑病,神经退行性疾病和妄想.
- 脑后神经系统疾病包括骨肌损伤,厌氧症,严重肌,吉兰-巴雷综合征,ICU获得的虚弱,以及COVID-19的后急性后果.
- 机制包括病毒进入大脑,细胞因子风暴,脑缺血和缺氧.
结论:
- SARS-CoV-2 感染对神经健康构成重大威胁,影响中枢神经系统和脑后神经系统.
- 了解这些机制对于开发有效的护理和治疗策略至关重要.
- 需要对COVID-19患者进行综合管理,这些患者会出现神经系统的后续症状,包括长期COVID-19症状.
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