膀管外逆流对儿科代移植功能的作用
Kelsi Alexander1, Sharon M Bartosh2, Weixiong Zhong2
1Department of Pediatrics, University of Wisconsin-Madison, Madison, USA. alexander.kelsi@outlook.com.
Pediatric nephrology (Berlin, Germany)
|September 18, 2024
概括
患有高度膀外流 (VUR) 的小儿移植患者面临着发烧性尿路感染 (UTI) 的更高风险. 然而,高度VUR不会影响这些年轻接受者的长期移植存活率.
科学领域:
- 儿科脏病学 儿科脏病学
- 移植免疫学 移植免疫学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 膀回流 (VESICOURETERAL REFLUX,简称VUR) 是儿童移植后的一种已知的并发症.
- 关于VUR对移植组织学和长期存活的影响的数据有限.
- 了解VUR的影响对于优化儿童移植后护理至关重要.
研究的目的:
- 调查VUR等级与儿科脏移植接受者的结局之间的关联.
- 评估VUR对移植功能,存活率和组织学变化的影响.
- 为了确定与VUR严重程度相关的尿路感染 (UTI) 的风险.
主要方法:
- 儿科移植患者 (2007-2020) 的回顾性审查.
- 在移植后6个月进行空白性囊电图 (VCUG),以V.UR等级.
- 在没有/低等级 (0-2) 和高等级 (3-5) VUR组之间比较结果 (移植失败,功能,尿路感染,蛋白尿,班夫分数).
主要成果:
- 分析了74名患者;39名没有/低度VUR,35名高度VUR.
- 在VUR组之间,移植失败率没有显著差异 (p=0.389).
- 高度VUR与整体尿路感染 (RR 1.89,p=0.041) 和发烧性尿路感染 (RR 1.66,p=0.038) 的风险增加有关.
结论:
- 患有高度VUR的儿科脏移植接受者更容易患有发烧性尿路感染.
- 在这个队列中,高度VUR不会对移植存活产生不利影响.
- 移植后6个月的VCUG对尿路感染风险分层有价值.
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