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在甲状腺相关的眼科医症中IL-17和IL-38基因多态
Ainura Mussakulova1, Altynay Balmukhanova2,3, Alua Aubakirova4
1Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
International ophthalmology
|September 18, 2024
概括
IL-17和IL-38细胞因子的遗传变异可能会影响甲状腺相关眼科医症 (TAO) 的发展. 一种特定的IL1F10多态 (rs3811058CC基因型) 在高加索格雷夫病患者中显示TAO风险增加.
科学领域:
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺相关眼病 (TAO) 是一种与格雷夫斯病 (GD) 相关的自身免疫性疾病,涉及轨道炎症和纤维化.
- 在IL-17和IL-38细胞因子中的基因多态性被假定会影响TAO的发展和进展.
研究的目的:
- 调查IL-17 (rs9463772 C/T在IL17F中) 和IL-38 (rs3811058 C/T,rs7570267 A/G在IL1F10中) 基因多态和TAO在Graves病患者中的关联.
- 在哈萨克斯坦人口中确定TAO的潜在遗传倾向.
主要方法:
- 一项病例控制研究涉及132名TAO患者和153名非TAO患者.
- 用TaqManTM Master Mix套件进行基因型鉴定.
- 基因组和基因型频率在各组之间进行了比较,对白种人进行了亚组分析.
主要成果:
- 吸烟者更容易发生TAO (OR=1.682,p=0.03).
- 在研究的基因多态和GD患者的TAO发育之间没有发现有意义的整体关联.
- 在高加索患者中,IL1F10 rs3811058 CC基因型 (OR=2.7,p=0.02) 和特定等位基因差异 (OR=2.8,p=0.001) 与TAO风险增加显著相关.
结论:
- 特定的IL1F10基因多态性 (rs3811058) 可能会在高加索GD患者中产生TAO的遗传倾向.
- 这些发现凸显了对影响TAO的遗传因素的进一步研究的需要.
- 鉴定的遗传关联可以为TAO开发新型治疗策略提供信息.
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