队列资料更新:约翰霍普金斯艾滋病毒临床队列,1989-2023年
Catherine R Lesko1, Anthony T Fojo2, Jeanne C Keruly2
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA. clesko2@jhu.edu.
European journal of epidemiology
|September 18, 2024
概括
约翰霍普金斯艾滋病毒临床队列在巴尔的摩追踪超过8000名艾滋病毒成年人,在30年内调整数据收集以研究不断变化的患者需求和艾滋病毒治疗结果.
科学领域:
- 临床流行病学临床流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 约翰霍普金斯艾滋病毒临床队列 (Johns Hopkins HIV Clinical Cohort) 成立于1989年,提供了艾滋病毒成年人的纵向数据.
- 它捕获了全面的临床信息,患者报告的结果和生物标本.
研究的目的:
- 更新约翰霍普金斯艾滋病毒临床队列的个人资料.
- 为了说明30年来巴尔的摩艾滋病毒阳性人口的变化.
- 证明数据收集的适应性,以满足艾滋病毒治疗的不断变化的研究需求.
主要方法:
- 从电子病历收集纵向数据.
- 通过标准化仪器包括患者报告的结果.
- 收集血和外周血液单核细胞,用于样本库.
- 对反映巴尔的摩艾滋病毒流行病的人口和临床数据的分析.
主要成果:
- 自1989年以来,该队列已经注册了8000多名个人.
- 在2021年,平均年龄为57岁,其中64%是男性,77%非西班牙裔黑人,37%是通过注射药物使用获得的艾滋病毒.
- 该队伍的人口统计数据反映了巴尔的摩30年来艾滋病流行病.
结论:
- 约翰霍普金斯艾滋病毒临床队列仍然是了解艾滋病毒治疗的重要资源.
- 队列的演变表明对艾滋病毒流行病和患者特征变化的反应能力.
- 调整确保在解决艾滋病毒和物质使用护理方面的研究差距方面保持相关性.
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