在慢性失眠中,局部功能连接的静态和时间动态变化
Jingwen Li1, Shumei Li2, Shaoqin Zeng2
1Department of Nuclear Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No.466 Road XinGang, Guangzhou, 510317, P. R. China.
Brain imaging and behavior
|September 18, 2024
概括
这项研究揭示了慢性失眠 (CI) 中大脑活动如何随着时间的推移而变化. 在右前的动态大脑连接性改变和右小脑的静态变化可能有助于识别CI患者.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 精神病学是一个精神病学.
背景情况:
- 慢性失眠 (CI) 与改变的内在神经活动有关.
- 在CI中这种神经活动的时间动态仍然未被充分探索.
- 了解这些动态对于阐明CI的神经基础至关重要.
研究的目的:
- 研究CI患者的区域同质性 (ReHo) 的静态和时间动态变化.
- 探索这些ReHo变化与CI的临床特征之间的关联.
- 评估ReHo指标在区分CI患者与健康对照 (HCs) 的诊断潜力.
主要方法:
- 87名CI患者和78名HC患者接受了休息状态功能磁共振成像 (fMRI).
- 使用静态和动态ReHo分析来评估本地功能连接.
- 相关性分析将改变的大脑区域与疾病持续时间和临床尺度联系起来;用于诊断能力评估的ROC分析.
主要成果:
- CI患者表现出右前的动态ReHo增加和右小脑的静态ReHo降低_6.
- 右前骨中的动态ReHo与抑郁症得分有负相关性.
- 静态ReHo在右小脑_6与认知 (命名) 评分正相关;结合的指标显示了诊断准确度的提高.
结论:
- 在CI患者中存在变化的局部功能连接,无论是静态的还是动态的.
- 这些大脑变化与情绪和认知症状有关,为CI的神经机制提供了洞察力.
- 结合静态和动态ReHo指标,显示了区分CI患者和HC患者的潜力.
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