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在饮用水中过多的诱导的甲状腺功能障碍中miRNA的作用
Zhihan Yang1,2,3, Yishan Dong1,2,3, Shuo Wang1,2,3
1Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
Biological trace element research
|September 18, 2024
概括
饮用水中过量的是甲状腺功能障碍的危险因素. 这项研究在患者中发现了miR-346和miR-204-5p的较低水平,这表明它们在甲状腺功能障碍发展中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 环境健康 环境健康
背景情况:
- 缺乏症的疾病是可以控制的,但过多的摄入会增加甲状腺功能障碍.
- 微RNAs (miRNAs) 在诱导的甲状腺功能障碍症中的作用尚不清楚.
- 过量的是甲状腺功能障碍的潜在危险因素.
研究的目的:
- 为了研究过多的水和甲状腺功能障碍之间的关系.
- 为了确定关键的microRNAs参与甲状腺功能障碍的发病.
- 为了探索特定的miRNAs在甲状腺功能障碍的诊断潜力.
主要方法:
- 对308名甲状腺功能障碍患者和对照群进行了后勤回归分析.
- 测量血清甲状腺蛋白 (Tg) 和炎症性细胞因子 (IFN-γ,IL-6,TNF-α).
- 高通量miRNA测序和选择的miRNAs的qRT-PCR验证.
主要成果:
- 水中>100微克/升是甲状腺功能障碍的独立危险因素.
- 在甲状腺功能障碍患者中观察到血清Tg和细胞因子 (IFN-γ,IL-6,TNF-α) 的升高.
- 甲状腺功能障碍症患者的miR-346和miR-204-5p水平显著降低,特别是>300微克/升.
结论:
- 过量的水可能导致miR-346和miR-204-5p的表达减少.
- 降低miR-346和miR-204-5p可能会导致Tg和细胞因子升高,促进甲状腺功能过高.
- miR-346和miR-204-5p显示出作为甲状腺功能增高的诊断生物标志物的潜力.
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