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一年长的大麻使用治疗医疗症状和在认知过程中的大脑激活

Debbie C L Burdinski^1,2, Alisha Kodibagkar^1,3, Kevin Potter^2,4

¹McGovern Institute for Brain Research, MIT, Cambridge, Massachusetts.

JAMA network open

|September 18, 2024

概括

治疗症状的医用大麻使用在一年内没有改变认知任务中的大脑激活. 对更高剂量和多样化的群体需要进一步的研究.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
医学大麻研究医学大麻研究

背景情况:

大麻越来越多地用于缓解医疗症状.
医用大麻对大脑功能的影响在很大程度上是未知的.

研究的目的:

调查一年的医用大麻使用与大脑激活之间的关联.
评估工作记忆,奖励和抑制控制认知功能的变化.

主要方法:

一项涉及寻求医用大麻卡的成年人队列研究.
功能神经成像 (fMRI) 用于在基线和一年后测量大脑激活.
参与者完成了认知任务,评估工作记忆,奖励和抑制控制.

主要成果:

在医用大麻使用者的基线和一年的随访期间,没有发现大脑激活的统计学意义上的差异.
在大麻使用频率的变化和大脑激活之间没有观察到任何关联.
对于认知过程的正规大脑激活在所有组中都存在.

结论:

一年使用医用大麻治疗症状并没有与大脑激活的显著变化有关.
未来的研究应该探索更高的剂量,更高的频率,更年轻的人口统计数据,以及更大,更多样化的队列.

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