血液细胞移植用于血液癌症的使用 根据种族,种族和年龄分类
Theresa Hahn1, Megan M Herr2, Ruta Brazauskas3,4
1Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
JAMA network open
|September 18, 2024
概括
从2009年到2018年,血液细胞移植 (HCT) 的利用率在所有组都增加了. 然而,非西班牙裔黑人患者在血液癌症治疗中接受HCT的差异仍然存在.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学 移植医学
背景情况:
- 血造细胞移植 (HCT) 是血液癌症的关键治疗方法.
- 之前的研究表明,基于种族,种族和年龄,HCT的使用差异很大.
研究的目的:
- 评估HCT使用的趋势随着时间的推移.
- 确定在HCT利用中是否存在基于种族,种族和年龄的差异.
- 在移植量增加的背景下,评估HCT利用率.
主要方法:
- 使用2009-2018年美国人口数据进行的回顾性队列研究.
- 包括有6种血液癌症的患者,接受了自主性或异种性HCT.
- 利用了监测,流行病学和最终结果 (SEER) 数据和国际血液和骨髓移植研究中心 (CIBMTR) 数据.
主要成果:
- 从2009年到2018年,HCT的使用在所有人口群体中都增加了.
- 在2017-2018年,非西班牙裔黑人患者与白人或西班牙裔患者相比,对AML和MDS的全基性HCT利用率较低.
- 对多发性骨髓瘤的自主HCT在非西班牙裔白人患者中最高.
结论:
- 尽管HCT使用总体上有所增加,但仍然存在显著的差异,特别是在非西班牙裔黑人患者中.
- 在西班牙裔,非西班牙裔其他和年轻人群体中,利用率有所改善,与非西班牙裔白人患者相比.
- 需要进行持续的监测和干预,以解决HCT访问中持续存在的不平等问题.
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