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在绿色药物分析的背景下,以岩素为基础的产品

Natália Sabina Dos Santos Galvão¹, Ana Carolina Kogawa¹

¹Federal University of Goiás, Laboratório de Controle de Qualidade, Faculty of Pharmacy, Goiânia, Goiás, Brazil.

Journal of AOAC International

|September 18, 2024

概括

本综述考察了药品中ivermectin (IVE) 的分析方法,强调了需要采用更绿色方法的需要. 大多数当前的方法缺乏环保性,为可持续的实验室实践提供了机会.

科学领域:

分析化学分析化学
绿色化学绿色化学
药品分析药品分析

背景情况:

伊弗梅克丁 (IVE) 是人类和动物健康中广泛使用的抗寄生虫药物.
药品中的IVE现有分析方法往往缺乏环保考虑.
化学和制药行业越来越需要可持续实践.

研究的目的:

为药物矩阵中的ivermectin提供分析方法的概述.
在绿色分析化学 (GAC) 的框架内评估这些方法.
确定增强分析程序环境友好性的机会.

主要方法:

对IVE分析方法的文献和汇编审查.
对方法特征的分析,包括使用的染色体技术和溶剂.
对分析的药物矩阵进行评估,重点是药片.

主要成果:

大多数审查的分析方法 (70%) 使用高性能液体染色学 (HPLC).
药片是最常被分析的药物矩阵 (37%).
甲醇和乙二是HPLC方法中最常见的溶剂,在50%以上的案例中使用,这表明绿色溶剂替代品的潜力.

结论:

对于ivermectin的分析方法可以调整,使其与绿色分析化学原则保持一致.
实施GAC为分析开发提供了可持续的工作机会.
本次审查强调了采用更绿色的分析策略对药物分析的重要性.

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