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Updated: Jun 12, 2025

Single-Molecule FRET Imaging for Observing the Conformational Dynamics of Dynamin-Like GTPase Atlastin
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Single-Molecule FRET Imaging for Observing the Conformational Dynamics of Dynamin-Like GTPase Atlastin

Published on: January 24, 2025

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对ATP稳定TDP-43原纤维细胞的原子洞察

Zhengdong Xu1, Jiaxing Tang2, Yehong Gong3

  • 1Department of Physical Education, Shanghai University of Engineering Science, 333 Long Teng Road, Shanghai 201620, People's Republic of China.

Journal of chemical information and modeling
|September 18, 2024
PubMed
概括

腺三酸盐 (ATP) 稳定了与ALS有关的有毒TDP-43蛋白聚合物. 分子动力学模拟显示,ATP结合增强了TDP-43纤维的形成和稳定性,为神经退行性疾病提供了潜在的治疗点.

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