痴呆的心血管风险与认知健康,中年个体的脑行为变化有关
Feng Deng1, Maria-Eleni Dounavi2, Emanuele R G Plini3
1School of Psychology, Shenzhen University, Shenzhen 518060, China.
Neurobiology of aging
|September 18, 2024
概括
心血管风险因素与健康的中年成年人的认知和大脑变化有关. 较高的风险分数与较差的认知和随着时间的推移而改变的大脑连接相关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知科学 认知科学
背景情况:
- 阿尔茨海默氏病 (AD) 的神经病理在症状出现前几十年就开始了.
- 早期发现AD风险因素对中年认知的影响至关重要.
- 在健康的中年人群中,AD风险因素与大脑变化之间的关系尚不清楚.
研究的目的:
- 调查阿尔茨海默病 (AD) 风险因素与认知功能之间的关联.
- 为了检查AD风险因素和功能连接 (FC) 在Locus Coeruleus (LC) 和海马之间之间的联系.
- 在认知健康的中年人群中,以横截面和纵向评估这些关联.
主要方法:
- 使用神经心理评估和功能磁共振成像 (fMRI).
- 在基线 (N=210) 和两年随访 (N=188) 收集的数据.
- 研究了与阿波利波蛋白 ε4 (APOE ε4) 基因型,家族痴呆史以及心血管风险因素,衰老和痴呆发病率 (CAIDE) 评分的相关性.
主要成果:
- 较高的CAIDE分数与较差的认知有交叉相关性.
- 更年期状态与有关认知的CAIDE风险相互作用.
- CAIDE评分调节了认知和LC-Hippocampus FC之间的关系.
- 在两年内,LC-海马FC在纵向上显著下降.
结论:
- 心血管风险因素与认知健康的中年个体的认知和大脑变化有关.
- 早期识别痴呆风险因素可以为干预提供信息.
- 中年大脑健康对于长期的认知健康至关重要.
相关概念视频
01:30Dementia
102
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
102
01:30Cognitive Development During Adulthood
66
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
66
01:26Alzheimer's Disease: Overview
451
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
451
01:27Psychoneuroimmunology: Cardiovascular Disease
26
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
26
01:26Aging
39
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
39
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
110
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
110