使用加利福尼亚州基于人口的SARS-CoV-2调查来定义长期COVID
Jake M Pry1, Kalyani McCullough2, Kristina Wen-Jeh Lai2
1California Department of Public Health, Richmond, CA, USA; School of Medicine, University of California, Davis, CA, USA; Center for Infectious Disease Research in Zambia, Lusaka, Zambia.
Vaccine
|September 18, 2024
概括
根据定义,对长期COVID患病率的估计有很大差异. 严重的初始COVID-19感染增加了患长期COVID的风险,接种疫苗可能会降低患病率.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 了解SARS-CoV-2负担和COVID (PASC) 或长期COVID的后急性连续病例的理解仍在不断发展,几年后进入大流行.
- 长期COVID的患病率估计仍然不一致和不确定.
- 大规模的血清监测研究对于完善这些估计至关重要.
研究的目的:
- 用五种不同的定义来评估长期COVID流行率估计.
- 在加利福尼亚州居民中确定长期COVID的预测因素.
- 分析疫苗接种对长期COVID流行影响.
主要方法:
- 由加利福尼亚州公共卫生部 (CDPH) 进行的横截面调查.
- 包括人口统计信息,临床症状和COVID-19疫苗接种史.
- 后勤回归分析以评估不同定义的长期COVID的流行率和预测因素.
主要成果:
- 分析包括2883名参与者,主要是女性 (62.5%),平均年龄为39岁.
- 根据定义,长期COVID的患病率各不相同,患病率最高 (20.9%) 是不完全康复,最低 (4.9%) 是严重的长期COVID.
- 完成初级疫苗接种系列与显著较低的长期COVID流行率有关.
结论:
- 根据所使用的定义,估计的长期COVID患病率存在显著差异.
- 经历严重初始COVID-19感染的个人患长期COVID的风险更高.
- 疫苗接种状态是影响长期COVID流行的一个重要因素.
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