在非综合征性先天性镜像运动中,横向准备系统的异常连接性
Xueyao Lu1, Elizabeth A Franz1, Stephen P Robertson2
1Action Brain and Cognition Lab, Department of Psychology, University of Otago, Dunedin, New Zealand.
概括
具有先天性镜像运动 (CMM) 的个体表现出延迟的大脑准备和增强的补充运动区域 (SMA) 和运动皮层 (M1) 连接. 这些神经差异可能代表终身镜像体验的神经补偿.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 神经生理学 神经生理学
背景情况:
- 非综合征性先天性镜像运动 (CMM) 呈现出复杂的表型.
- 体和皮质脊髓管中的异常与CMM镜像运动有关.
- 响应准备网络,包括补充运动区域 (SMA) 和运动皮质 (M1),是潜在的功能障碍区域.
研究的目的:
- 在CMM患者中调查SMA-M1响应准备网络的功能完整性.
- 测试该假设,该网络内的异常功能有助于CMM表型.
- 探索CMM中神经活动,功能连接和行为表现之间的关系.
主要方法:
- 对CMM (n=12) 和对照组 (n=28) 的参与者进行了一项概率化的Go-NoGo任务.
- 使用脑电图 (EEG) 来记录任务期间的大脑活动.
- 评估了侧面准备潜力和SMA-M1功能连接.
主要成果:
- 患有CMM的参与者表现出延迟的横向准备潜力,表明自愿运动准备速度较慢.
- 在CMM组中,左半球SMA和M1区域之间观察到更强的功能连接.
- SMA-M1连接的强度与行为表现相关,但与镜子运动的严重程度无关.
结论:
- 在CMM中神经异常扩展到参与运动准备的脑网络,在直接运动输出的上游.
- 观察到的功能连接模式表明,在经历镜子运动的一生中,潜在的神经补偿机制得到了发展.
- 这些发现凸显了神经可塑性在适应CMM带来的独特挑战方面的作用.
关键词:
产生的镜像运动 (CMM)功能连接性的功能连接性.在LRP中使用LRP.发动机准备工作 发动机准备工作神经补偿是一种神经补偿.SMA - M1 - M1 - M1 - M1 - M1 - - M1 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
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