社会激励与货币激励对急性炎症下抑制控制的不同影响
Gabriella M Alvarez1, Tatum A Jolink2, Taylor N West3
1Department of Psychology, University of Pittsburgh, Pittsburgh, PA USA; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Brain, behavior, and immunity
|September 18, 2024
概括
通过IL-6测量的急性炎症会影响认知表现,特别是提高对高价值社会激励的准确性. 这表明,炎症会影响我们如何应对日常生活中的奖励.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 免疫学 免疫学 免疫学
背景情况:
- 已知慢性炎症与神经退行性疾病中的认知衰退的联系.
- 急性炎症对日常认知功能的影响仍未得到充分研究.
- 洲际蛋白-6 (IL-6) 是一个关键的炎症标记物.
研究的目的:
- 研究IL-6水平急性变化与认知表现之间的关联.
- 检查激励类型 (社会/货币) 和规模如何影响这种关联.
- 为了评估与IL-6变化相关的抑制控制任务 (去/不去) 的性能.
主要方法:
- 参与者内部设计使用激励的去/不去任务.
- 参与者在接种流感疫苗之前和之后完成了任务.
- 多级逻辑回归分析了试验级数据 (Nobs = 30,528).
主要成果:
- 没有显著的IL-6反应性和准确性变化之间的关联,对于没有去试验.
- 在GO试验中,IL-6反应性和激励条件之间存在显著的相互作用.
- 增加的IL-6反应性与较低的错误相关,高规模的社会激励与货币或低规模的社会激励相比.
结论:
- 急性炎症可能会改变激励评估和注意力资源分配.
- 轻微的炎症波动可以影响对日常生活至关重要的认知能力.
- 突出了IL-6在调节社会奖励条件下的抑制控制中的作用.
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