代谢和体重成分对发生喘的影响,使用现实世界的队列队列
Melissa H Bloodworth1, Patrick J Staso1, Shi Huang2
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
概括
肥胖和糖尿病增加了成人喘的风险. 通过预防和治疗来控制体重和糖尿病,可以降低患喘的可能性.
科学领域:
- 肺部医学 肺部医学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 肥胖和代谢失调 (MetD) 越来越普遍.
- 这些情况会对喘的严重程度和治疗的有效性产生负面影响.
研究的目的:
- 为了研究体重和MetD对成人发作的喘发展的影响.
- 为了确定与喘风险相关的MetD的特定组件.
主要方法:
- 对90,081名患者进行了回顾性纵向队列研究.
- 在3年时间内进行喘诊断时间分析,评估体重和MetD.
- 评估与MetD组件和体重相关的发生性喘风险.
主要成果:
- 糖尿病在基线,但不是其他MetD组件,显著增加了喘风险 (aHR=1.85).
- 超重和肥胖造成了15.4%的10年可归因性喘风险,独立于其他MetD因素.
- 没有患上喘的糖尿病患者表现出较低的HbA1c水平和更频繁的甲福林使用.
结论:
- 体重管理和糖尿病控制是预防成人喘的关键可修改的风险因素.
- 针对肥胖和糖尿病的干预措施可能会减少成人喘发病率.
相关概念视频
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
Asthma: Pathogenesis and Management
364
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
364
Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
245
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
245


