针对损伤:慢性病中的ACE2/Ang-(1-7) /mas轴
1Department of Pathology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, PR China.
Cellular signalling
|September 18, 2024
概括
氨酸- ангиотензин系统 (RAS) 轴ACE2/Ang-(1-7) /Mas显示出治疗慢性病 (CKD) 的前景. 针对这种途径可能提供新的治疗策略,以减缓CKD进展并改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 氨酸- ангиотензин系统 (RAS) 显著影响慢性病 (CKD) 的进展.
- 经典的ACE/Ang II/AT1轴激活会使损伤,炎症和纤维化恶化.
- 在CKD中,ACE2/Ang-(1-7) /Mas轴具有潜在的保护机制.
研究的目的:
- 综合审查ACE2/Ang-(1-7) /Mas轴在CKD发病过程中的作用.
- 系统地检查针对这一特定RAS轴的治疗分子和药物.
- 确定延迟或阻止CKD进展的潜在策略.
主要方法:
- 对CKD中ACE2/Ang-(1-7) /Mas轴研究的文献综述.
- 对针对该途径的药物剂的研究分析.
- 综合发现,以评估治疗潜力.
主要成果:
- 在各种CKD模型中,ACE2/Ang-(1-7) /Mas轴显示出脏保护作用.
- 针对这一轴的几个分子和药物在临床前研究中显示出有前途.
- 调节这个轴提供了一个潜在的治疗途径来管理CKD.
结论:
- ACE2/Ang-(1-7) /Mas轴是新型CKD治疗的关键目标.
- 针对这种途径的进一步研究可能会导致更有效的治疗方法.
- 专注于这一轴的干预措施可能有助于在CKD患者中保持功能.
相关概念视频
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
396
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
396
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
492
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
492
01:25Antihypertensive Drugs: Direct Renin Inhibitors
508
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
508
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
600
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
600
01:27Dialysis
276
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
276
01:20Renal Corpuscle
1.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K