对于食道癌的右胸部与左胸部方法的十年生存率
Bin Li1, Zezhou Wang2, Yihua Sun1
1Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China; Institute of Thoracic Oncology, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
The Annals of thoracic surgery
|September 18, 2024
概括
在食道癌患者的食道切除术中,右胸部方法与左侧方法相比,证明了改善的长期存活率. 这种生存益处在淋巴结转移的患者中尤为显著.
科学领域:
- 手术瘤学手术瘤学
- 胸部外科手术 胸部外科手术
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 食道切除术是食道癌治疗的关键手术.
- 手术技术的变化可能会影响患者的治疗结果.
- 了解不同手术方法的长期影响对于优化食道癌症护理至关重要.
研究的目的:
- 评估外科手术对食道癌患者长期生存的影响.
- 为了比较左侧和右侧胸腔食道切除术之间的无疾病生存率 (DFS) 和整体生存率 (OS).
- 确定可能从特定的手术方法中获益更多的患者子组.
主要方法:
- 一个随机试验,涉及300名患有食道癌症的患者.
- 患者被分配到左侧或右侧胸腔食道切除方法.
- 在286名患有食道状细胞癌的患者中,分析了无病生存率 (DFS) 和整体生存率 (OS).
主要成果:
- 右胸部方法显示DFS的中位数为92个月,而左侧的DFS为41个月 (P = .045).
- 累计10年的DFS为右臂的47.6%,左臂的37.5%.
- 对于淋巴结转移的患者,10年DFS和OS在右胸部方法下显著改善 (分别P=0.018和P=0.012).
结论:
- 对食道切除术的右胸部方法与左胸部方法相比,与更高的10年生存率有关.
- 右胸部方法的存活优势在患有淋巴结转移的食道癌患者中尤为明显.
- 这些发现支持考虑正确的胸部方法,以改善精选食道癌症患者的长期结果.
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