在PROGRESS队列中,产前暴露于甲酸盐和儿童喘息和喘
Cecilia S Alcala1, Hector Lamadrid-Figueroa2, Marcela Tamayo-Ortiz3
1Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA.
The Science of the total environment
|September 18, 2024
概括
产前接触某些酸盐与儿童喘息和喘有关,影响因性别而异. 墨西哥城的这项研究强调了这些重要的环境健康风险.
科学领域:
- 环境健康 环境健康
- 儿科呼吸系统医学 儿科呼吸系统医学
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于酸盐,无处不在的环境化学物质,可能会影响儿童的肺部发育.
- 酸盐暴露和呼吸道问题 (如喘息和喘) 之间的关联可能在性别之间有所不同.
- 关于拉丁美洲人口中这些关联的流行病学数据有限.
研究的目的:
- 调查产前甲酸代谢物度与墨西哥儿童呼吸系统结果之间的关联.
- 探索产前甲酸盐暴露对喘息和喘发展的潜在性别特异性影响.
主要方法:
- 在墨西哥城的593个母婴二合体中,在母亲的尿液中分析了15种甲酸代谢物.
- 在4岁和6岁时使用验证的调查评估喘息和喘.
- 修改Poisson和贝叶斯加权量子总和 (BWQS) 回归模型的应用,对共变量进行调整.
主要成果:
- 在第二个三个月内暴露于单一 (碳氧-异尼尔) 甲酸盐 (MCNP) 与4岁时喘息和喘风险增加有关.
- 在第二个三个月内,二异尼尔甲酸盐 (DiNP) 代谢物的度较高与4岁时的喘有关.
- 观察到性别特异性影响,男性中甲酸盐混合物与喘之间存在较强的关联,女性中与喘息相反的关联.
结论:
- 产前甲酸代谢物水平与儿童呼吸系统问题有关,这表明潜在的性别特异性影响.
- 对甲酸盐暴露,喘息轨迹和肺功能进行进一步的研究对于了解长期疾病预测至关重要.
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