液体活检在神经母细胞瘤中的作用:一个范围审查
Jitender Singh1, Nitin J Peters1, Pramod Avti2
1Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Journal of pediatric surgery
|September 18, 2024
概括
液体活检生物标志物在彻底改变神经母细胞瘤 (NBL) 诊断和监测方面表现有前途. 这种非侵入性方法为儿科瘤学提供了精密医学的进步,改善了患者的治疗结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 分子诊断学 分子诊断
- 癌症生物标志物 癌症生物标志物
背景情况:
- 神经母细胞瘤 (NBL) 是一个常见的儿童固体瘤,具有复杂的诊断和预后挑战.
- 液体活检提供了一种通过循环生物标志物进行瘤检测和监测的非侵入性方法.
- 准确的诊断和监测对于有效的NBL管理至关重要.
研究的目的:
- 对基于液体活检的神经母细胞瘤生物标志物进行范围审查.
- 探索这些生物标志物的临床影响,挑战和未来前景.
- 综合目前关于NBL液体活检应用的证据.
主要方法:
- 根据PRISMA-ScR指南进行了范围审查.
- 在主要数据库 (PubMed,EMBASE,Scopus,Web of Science) 中进行了全面的文献搜索.
- 在NBL中对液体活检生物标志物的研究被系统地识别和分析.
主要成果:
- 在最初确定的201项研究中,选出了15项研究.
- 主要的液体活检生物标志物包括循环瘤细胞 (CTC),循环瘤DNA (ctDNA) 和外体.
- 评估了生物标志物与整体存活率,无事件存活率和NBL风险分层的相关性.
结论:
- 液体活检生物标志物具有改变NBL诊断和治疗监测的巨大潜力.
- 这一领域正在迅速发展,为儿科NBL管理中的精密医学铺平了道路.
- 需要进一步的研究,才能将这些生物标志物完全纳入临床实践.
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