PNI对于预测软组织肉瘤患者的预后是有用的:一项回顾性研究
Keiju Saito1, Yusuke Kawabata1, Ikuma Kato2
1Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Japan.
概括
预后营养指数 (PNI) 是软组织肉瘤患者整体生存的有价值预测指标. 较高的PNI水平与显著更好的生存结果相关,将其确立为关键的预后因素.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 营养生物标志物 营养生物标志物
背景情况:
- 术前预后营养指数 (PNI) 已被公认为其在胃肠道疾病的预后效用.
- 改善手术前营养状况与更好的患者结果有关.
- 有限的大规模研究已经探索了PNI的预后价值,特别是在软组织肉瘤中.
研究的目的:
- 调查预后营养指数 (PNI) 对软组织肉瘤患者的整体生存期的预后价值.
- 确定PNI是否可以作为软组织肉瘤预后的预测生物标志物.
主要方法:
- 在2006年1月至2022年3月期间被诊断患有软组织肉瘤的111名患者的回顾性分析.
- 从预处理血液样本计算营养和炎症生物标志物,包括PNI.
- 使用Kaplan-Meier方法,日志等级测试和Cox比例危险模型进行单变量和多变量分析的生存分析.
主要成果:
- 与低PNI组相比,高PNI组的患者的整体存活时间明显长 (p < 0.0001).
- 结果显示,PNI是对整体存活时间最重要的单变性预后因素 (HR:5.64,p = 0.0002).
- 多变量分析证实PNI是一个独立的预后因素,即使考虑到阶段,年龄和瘤位置 (HR:7.02,p = 0.0002).
结论:
- 预后营养指数 (PNI) 是一个有价值的预后因素,用于预测软组织肉瘤患者的整体存活率.
- PNI表现出显著的预测能力,优于其他营养和炎症标志物.
- 这些发现支持在临床实践中使用PNI用于软组织肉瘤风险分层和管理.
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