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腹腔镜Roux-en-Y vs 一次解肠胃旁路术后肠道微生物群的短期转移:多中心随机对照试验结果

Flavio De Maio¹, Cristian Eugeniu Boru², Nunzio Velotti³

¹Dipartimento Di Scienze Di Laboratorio E Infettivologiche, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Surgical endoscopy

|September 18, 2024

概括

腹腔外科手术显著改变严重肥胖患者的肠道微生物群. 一个解肠胃绕道 (OAGB) 和Roux-en-Y胃绕道 (RYGB) 都会对肠道细菌和代谢健康产生类似的影响.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
代谢手术代谢手术

背景情况:

腹腔/代谢手术 (BMS) 程序,如Roux-en-Y胃绕道 (RYGB) 和一个解肠胃绕道 (OAGB) 是严重肥胖的常见病例.
绕道手术后肠道微生物群 (GM) 的变化是影响患者结果的重要但经常被低估的因素.

研究的目的:

为了比较OAGB后的肠道微生物群概况与手术后24个月的RYGB.
评估这些微生物群变化对新陈代谢和营养状况的影响.

主要方法:

一个前性的多中心随机对照试验 (RCT),涉及严重肥胖患者.
便和血液样本在手术前和手术后24个月使用16SrRNA测序进行基因转基因分析.

主要成果:

在OAGB和RYGB组中,微生物α和β多样性的显著下降.
动态细菌和蛋白质细菌的相对丰度增加,而细菌类减少,导致更高的Firmicutes/Bacteroidetes比率.
在OAGB和RYGB组之间没有观察到转基因变化或代谢参数的显著差异.

结论:

腹腔外科手术诱导肠道微生物群组成的深刻变化.
手术技术 (OAGB与RYGB) 在24个月后没有对GM或代谢参数产生差异性影响.
手术后的转基因资料可以作为预测中长期减肥手术结果的生物标志物.

关键词:

腹腔/代谢手术是什么意思我们的肠道微生物群.微生物多样性的微生物多样性.致病性肥胖症是一种病态的肥胖症.一个解剖肠胃绕道.在Roux-en-Y的胃旁路术中.

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