晚餐与结直肠腺瘤的关联:一个横截面研究
Darbaz Adnan1, Edena R Khoshaba1, Mostafa Abel-Reheem1
1Rush Center for Integrated Microbiome and Chronobiology Research, Rush Medical College, Rush University Medical Center, Chicago, IL, 60612, USA.
European journal of nutrition
|September 18, 2024
概括
晚餐,定义为在睡眠后3小时内食用食物,增加患结肠管状腺瘤 (TA) 的风险. 这一发现表明,饮食时间,一种昼夜干扰的形式,是结肠癌发生的一个重要因素.
科学领域:
- 胃肠道学和瘤学
- 时间生物学 时间生物学
- 生活方式 医学 医疗
背景情况:
- 结肠直肠癌 (CRC) 率在年轻人群中正在上升,这表明除了遗传之外还有未知的病因因素.
- 生活方式暴露是已知的CRC的贡献者,但特定的时间相关因素需要进一步调查.
研究的目的:
- 调查晚餐模式与癌前结肠瘤,特别是管状腺瘤 (TA) 的风险之间的联系.
- 探索饮食时间作为结肠癌发生的潜在因素的作用.
主要方法:
- 一组663名接受查结肠镜检查的参与者通过问卷提供了关于食物时间,饮食和睡眠模式的数据.
- 晚餐被定义为每周至少四天在睡眠开始后3小时内食用食物.
- 腺瘤组织学和风险类别通过病理学报告得到证实.
主要成果:
- 在644名符合条件的参与者中,42.2%被归类为晚餐者.
- 与不吃晚饭的人相比,吃晚饭的人患管状腺瘤 (TA) 的几率明显更高 (OR=1.46,p=0.023).
- 在调整了混因子 (OR=1.98,p=0.008) 之后,这种关联仍然显著,确定晚餐是高风险和多重TA的独立风险因素.
结论:
- 晚餐被确定为结肠管状腺瘤发展的新风险因素.
- 循环节障碍,特别是与摄入食物的时间有关,可能在结肠瘤形成中发挥关键作用.
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