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泰利多米德对COVID-19患者有效性的分子机制解释:ACE2是一种新的ΔNp63α向基因

Laura Monteonofrio¹, Ilaria Virdia¹, Sara Pozzi²

¹Dipartimento Di Ricerca E Tecnologie Avanzate, Istituto Nazionale Tumori Regina Elena IRCCS, 00144, Rome, Italy.

Journal of molecular medicine (Berlin, Germany)

|September 18, 2024

概括

thalidomide以p63-依赖的方式降低ACE2 (血管酶转化酶2),减少SARS-CoV-2的进入并减轻COVID-19相关的炎症. 这种药物为病毒感染提供了双重治疗方法.

科学领域:

分子生物学分子生物学
病毒学病毒学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

SARS-CoV-2病毒使用ACE2进入细胞,使ACE2成为COVID-19治疗的关键目标.
已知具有免疫调节作用的thalidomide已被提议用于COVID-19管理中的重新定位.
在COVID-19中,细胞因子风暴条件涉及ACE2的稳定和IL-8产量的增加.

研究的目的:

为了研究将thalidomide,ACE2和COVID-19病原体联系在一起的分子机制.
为了探索thalidomide抑制SARS-CoV-2进入和减少炎症的潜力.

主要方法:

在细胞因子风暴条件下研究了p63和ACE2基因之间的相互作用.
评估了thalidomide和lenalidomide对ACE2表达的影响.
在thalidomide治疗后通过伪SARS-CoV-2进行体外感染的评估.

主要成果:

p63与ACE2基因表达结合并调节,在细胞因子风暴条件下稳定ACE2.
thalidomide和lenalidomide治疗以p63-依赖的方式降低了ACE2的表达.
thalidomide治疗减少了由伪SARS-CoV-2引起的体外感染.

结论:

沙利多米德具有双重作用:通过降解p63降低ACE2通过降低ACE2通过降低ACE2通过降低ACE2通过降低ACE2通过降低ACE2,并减轻肺炎.
thalidomide对ACE2的调节为COVID-19和其他依赖ACE2的感染提供了一个有希望的治疗策略.
这些发现支持thalidomide在治疗SARS-CoV-2感染及其相关炎症反应方面的临床实用性.

关键词:

在ACE2中,ACE2是ACE2.在COVID 19 疫情下,这就是SARS-CoV-2病毒.泰利多化物是一种的 ΔNp63α.

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