与早产有关的草甘和氨基甲基酸的妊娠性尿度:MIREC研究
Jillian Ashley-Martin1, Leonora Marro2, James Owen2
1Environmental Health Research and Science Bureau, Health Canada, Ottawa, ON, Canada. jillian.ashley-martin@hc-sc.gc.ca.
Journal of exposure science & environmental epidemiology
|September 18, 2024
概括
在加拿大的一项研究中,尿草甘及其代谢物AMPA与早产 (PTB) 或更短的妊娠时间无关. 这项研究发现,暴露于这些常见的除草剂化合物和不良出生结果之间没有联系.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 有限的高质量研究存在于尿草甘,其降解AMPA和早产 (PTB) 之间的联系.
- 了解这些关联对于公共卫生和环境安全至关重要.
研究的目的:
- 在泛加拿大环境化学品母婴研究 (MIREC) 队列中量化尿液中的草甘和AMPA水平与早产 (PTB) 之间的关联.
- 根据胎儿的性别调查这些关联的潜在差异.
主要方法:
- 来自1880年加拿大孕妇的第一季度尿液样本被分析为草甘和AMPA.
- 过早分娩 (PTB),自发过早分娩 (sPTB) 和妊娠年龄被评估为结果.
- 离散时间生存分析和逻辑回归模拟PTB/sPTB风险;线性回归评估妊娠年龄,按胎儿性别分层.
主要成果:
- 6%的出生是早产,4.7%是自发的早产.
- 尿液中的草甘和AMPA度中位数分别为0.25微克/升和0.21微克/升.
- 在草甘或AMPA水平与PTB,sPTB或妊娠年龄之间没有发现显著的关联,没有证据表明受胎儿性别影响的影响.
结论:
- 在这个加拿大队列中,草甘和AMPA的尿度与早产或妊娠时间缩短无关.
- 这些发现表明,常见的环境暴露在草甘和AMPA中可能不是这一群体中PTB的重要风险因素.
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