不完美的骨质生成中的牙异常:系统性审查
Laura Ventura1,2,3,4, Sara J E Verdonk3,4,5, Lidiia Zhytnik1,2,3,4
1Department of Human Genetics, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Calcified tissue international
|September 18, 2024
概括
骨质发育不完善 (OI) 患者经常经历牙问题,如牙发育不完善 (DI) 和缺陷. 严重的OI类型显示出更多的牙异常,而不是较轻的类型,突出显示出需要牙护理.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 口腔医学是指口腔医学.
- 儿科牙科 儿科牙科
背景情况:
- 骨质变生不完美 (OI) 是一种罕见的遗传疾病,导致骨脆弱和形.
- 牙异常,包括牙生殖不完美 (DI),缺陷和未爆发的牙,在OI患者中很常见.
研究的目的:
- 综合审查和评估骨质变性不完美 (OI) 群体中牙异常的流行情况.
- 探索不同OI临床类型和病原性变体之间牙科问题的变化.
主要方法:
- 在PubMed,Embase和Web of Science中按照PRISMA指南进行了系统的文献搜索,直到2024年6月.
- 在672篇选文章中,包括了34项研究.
主要成果:
- 牙异常在OI中很普遍,牙生殖不完美 (DI) 影响20-48%的患者.
- 严重的OI类型 (III/IV) 比较轻度的OI类型 (OI I) 有更多的牙科问题;OI类型V通常缺乏DI.
- 不良闭塞的患病率各不相同 (I类:14.8-50%,II类:0-37.5%,III类:4.1-84%),而III类不良闭塞比一般人群更为常见. 在OI类型III和IV中,开口咬牙,交叉咬牙和未爆发的/缺失的牙是常见的.
结论:
- 对于患有骨质发育不完善 (OI) 的人来说,全面的牙科检查至关重要,因为牙异常的患病率很高.
- 在OI的背景下,需要更明确的诊断指南来诊断不完美的牙发育 (DI).
关键词:
一种类型I的原体.牙的异常 牙的异常牙生殖不完美症 (Dentinogenesis Imperfecta) 是一个骨质发生不完美症 (osteogenesis imperfecta) 是一个不完美的疾病.更多相关视频
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