基于丹麦人口的家族性和儿童癌症研究
Corbin C Platamone1, Chuanjie Deng1, Rajarshi Mazumder2
1Department of Epidemiology, Fielding School of Public Health, University of California (UCLA), Box 951772, Los Angeles, CA, 90095-1772, USA.
European journal of epidemiology
|September 18, 2024
概括
孕妇和怀孕期间使用抗药可能会增加儿童癌症的风险,包括白血病和中枢神经系统瘤. 需要进一步的研究来证实这些关联,并了解潜在的机制.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 关于母亲/婴儿,怀孕期间使用抗药和儿童癌症之间的联系存在不一致的发现.
- 了解这些关联对于公共卫生和临床实践至关重要.
研究的目的:
- 调查孕妇,儿童和怀孕期间使用抗药与儿童癌症风险之间的联系.
- 使用可靠的统计方法量化风险.
主要方法:
- 利用丹麦国家数据库来诊断和儿童癌症以及使用抗药.
- 使用条件逻辑回归来估计各种儿童癌症的调整几率比率.
- 分析了与孕产妇,儿童和孕产妇抗发作药物暴露的关联.
主要成果:
- 孕产妇与所有儿童癌症都有积极的关联,特别是急性淋巴细胞白血病 (OR=1.68) 和威尔姆斯瘤 (OR=2.13).
- 母亲一生使用抗药与所有癌症 (OR=1.14),中枢神经系统 (CNS) 瘤 (OR=1.36) 和神经母细胞瘤 (OR=1.76) 的风险增加有关.
- 孕妇在怀孕前或怀孕期间使用抗药与中枢神经系统瘤有关 (OR=1.99).
结论:
- 孕妇和怀孕期间使用抗药物是某些儿童癌症的潜在危险因素.
- 研究结果强调,需要仔细考虑在怀孕期间治疗和服用药物.
- 需要进一步的研究来阐明因果途径,并告知预防策略.
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