缺血性中风重症患者的基数过剩和死亡率之间的关联:一个回顾性队列研究
Jueheng Liu1, Jiamei Li1, Xuting Jin1
1Department of Critical Care Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
BMC neurology
|September 18, 2024
概括
进入ICU的危急性缺血性中风患者的低基过量 (BE) 与较高的死亡率有关. 这一发现突出了BE作为潜在的中风预后标志物.
科学领域:
- 关键护理医学 关键护理医学
- 神经学 神经学
- 生物化学 生物化学
背景情况:
- 基过量 (BE) 是各种疾病中已知的死亡率预测因素.
- 在缺血性中风患者中BE的预后意义仍然不清楚.
- 这项研究研究了初始BE水平与重症中风患者的死亡率之间的关联.
研究的目的:
- 为了确定入院基数过剩 (BE) 与重症监护室 (ICU) 缺血性中风患者的死亡率之间的关系.
- 评估BE对短期 (ICU,医院,28天) 和长期 (1年) 死亡率的影响.
- 探索顺序性器官衰竭评估 (SOFA) 评分对BE的预后价值的影响.
主要方法:
- 分析了1572名缺血性中风患者的队列.
- 多变量逻辑回归和考克斯比例危险模型评估了BE和死亡率之间的关联.
- 相互作用和子组分析通过SOFA评分 (≥5比<5) 评估了效果修改.
主要成果:
- 在BE和死亡风险之间观察到U形关系.
- 低BE (<-3 mmol/L) 与急症监护室,医院,28天和1年死亡率的增加显著相关.
- 这些关联在不同的SOFA分数层中保持一致.
结论:
- 在ICU入院时,初始基数过剩 (BE) < -3 mmol/L 是危急性缺血性中风患者死亡率增加的重要预测因素.
- 在这个人群中,BE作为短期和长期结果的有价值的预后指标.
- 根据SOFA评分,无论疾病的严重程度如何,BE的预后效用是显而易见的.
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