身体活动和患上8种与年龄有关的疾病的风险:流行病学和门德尔随机化研究
Jie Zhao1,2, Zezhi Ke1,2, Rihua Huang3
1College of Health Science, Guangdong Pharmaceutical University, Guangzhou, Guangdong, P.R. China.
概括
定期体育活动与患上几种与年龄有关的疾病,包括心脏病和糖尿病的风险降低有关. 门德尔随机化进一步支持大力活动和降低疾病风险之间的因果关系.
科学领域:
- 心血管健康 心血管健康
- 老年学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 通过年轻成年人冠状动脉风险发展 (CARDIA) 研究,研究了体力活动和与年龄相关的疾病之间的关联.
- 采用孟德尔的随机化 (MR) 来探索身体活动与8种特定的与年龄有关的疾病之间的因果关系.
研究的目的:
- 描述身体活动水平与患上与年龄相关疾病的风险之间的联系.
- 使用孟德尔随机化评估因果关系.
主要方法:
- 利用来自CARDIA研究的数据对五种疾病进行观察分析:冠状动脉心脏病,高血压,糖尿病,高脂血症和静脉血栓栓塞.
- 采用二进制物流回归来分析身体活动与疾病风险之间的关联.
- 应用孟德尔随机化,使用来自英国生物银行研究的全基因组关联研究对体力活动 (有力的和基于加速计) 的数据.
主要成果:
- 心脏分析显示,身体活动与冠状动脉心脏病,高血压,糖尿病和高脂血症的风险有关.
- 核磁共振结果表明,基因决定的剧烈体力活动与心痛,高血压和2型糖尿病的风险之间存在负因果关系.
- 此外,MR还支持了基于加速度计的体力活动与胸痛风险之间的负因果关系.
结论:
- 促进体育活动是预防特定与年龄有关的疾病的可能策略.
- 研究结果表明,身体活动对心血管和代谢疾病起着保护作用.
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