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Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

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An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
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Atomic Nuclei: Nuclear Relaxation Processes01:23

Atomic Nuclei: Nuclear Relaxation Processes

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In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis,  the precessing magnetic moments are randomly oriented around the z-axis.
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Energy Diagrams - II01:10

Energy Diagrams - II

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Energy diagrams are important to understand the dynamics of a system. The topology of an energy diagram helps illustrate the equilibrium points of the system.
The point in the energy diagram at which the system’s potential energy is the lowest is known as the local minima. The system tends to stay in this position indefinitely unless acted upon by a net force. The slope of the potential energy diagram at the local minima is zero, indicating that zero net force is acting on the system. The...
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Deindividuation00:57

Deindividuation

26.3K
Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.
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Hindsight Biases01:12

Hindsight Biases

3.4K
Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now? 
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Reversible and Irreversible Processes01:14

Reversible and Irreversible Processes

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The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...
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相关实验视频

Updated: Jun 12, 2025

High-Speed Magnetic Tweezers for Nanomechanical Measurements on Force-Sensitive Elements
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High-Speed Magnetic Tweezers for Nanomechanical Measurements on Force-Sensitive Elements

Published on: May 12, 2023

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从未解决的事件中发现不平衡.

Pedro E Harunari1

  • 1Complex Systems and Statistical Mechanics, Department of Physics and Materials Science, <a href="https://ror.org/036x5ad56">University of Luxembourg</a>, L-1511 Luxembourg, Luxembourg.

Physical review. E
|September 19, 2024
PubMed
概括

本研究引入了新的无模型工具,用于检测和量化复杂系统中的不平衡热力学. 这些方法分析了多层事件,甚至在有限的数据上也提供了对生产率的见解.

科学领域:

  • 热力学是一种热力学.
  • 统计力学 统计力学
  • 复杂的系统复杂的系统.

背景情况:

  • 检测和量化热力学不平衡对于理解复杂的自然系统至关重要.
  • 不平衡热力学经常使用粗粒度处理部分信息,模仿实验约束.
  • 由多个底层马尔科夫过程过渡产生的多层事件,代表了一个常见但未被充分探索的场景.

研究的目的:

  • 开发无模型工具,用于评估多层事件的非马科夫统计数据.
  • 提供检测不平衡行为和估计复杂系统中产生的方法.
  • 放松现有框架中的假设,以更好地分析多层次事件.

主要方法:

  • 在第一通道问题框架中放松一个关键假设,以分析多层事件.
  • 利用事件分布和等待时间的不对称性.
  • 在参考模型上使用分析和数值插图.

主要成果:

  • 引入无模型工具来检测不平衡行为.
  • 估计来自多层事件的生产率.
  • 讨论工具在不同系统和制度中的适用性,提供不同程度的信息,从没有到确切的产值.

结论:

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  • 开发的工具为研究多层事件的系统中的非平衡热力学提供了一种多功能方法.
  • 这些方法对于推断热力学属性即使在实验限制和部分信息下也是有价值的.
  • 这些发现有助于更深入地了解复杂的,潜在的非马科夫过程中的产生.