用于局部伤口愈合应用的瓦尼林加载-物理交联PVA/奇托桑/伊塔康膜
El-Refaie Kenawy1, Elbadawy A Kamoun2,3,4, Samia M Elsigeny5
1Department of Chemistry, Faculty of Science, Polymer Research Group, University of Tanta, Tanta, Egypt.
Journal of applied biomaterials & functional materials
|September 19, 2024
概括
这项研究使用冷解方法开发了含素的水凝膜 (PVA-CS-IA). 这些新型抗菌带显示出用于伤口愈合应用的有前途潜力.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 水凝膜对于伤口愈合和药物输送至关重要.
- 开发具有增强性质和抗菌活性的先进水凝是必不可少的.
研究的目的:
- 为了合成和表征瓦尼林载荷的物理交联水凝膜 (PVA-CS-IA).
- 评估开发的水凝膜的物理化学特性,生物相容性和抗菌疗效.
主要方法:
- 用三周期冷解 (F-T) 方法制备水凝膜.
- 评估了物理化学性质 (胀,机械,降解,热稳定性).
- 细胞活力 (MTT测定) 和抗菌活性对*黄金葡萄球菌*和*大肠杆菌*进行了评估.
主要成果:
- 增加的奇托桑/伊塔康酸 (CS-IA) 含量改善了胀,机械性能和水解性降解.
- 凝分量的百分比随着CS-IA含量增加而下降.
- 所有水凝都显示出显著的细胞活力和显著的抗菌活性.
结论:
- PVA-CS-IA水凝膜具有有利的物理化学和生物特性.
- 这些含瓦尼林的水凝显示出抗菌带的潜力,可以加速伤口愈合.
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