基因多态性和环境因素对暴露于COEs的工人的血压的影响和相互作用
Jing Sun1,2, Yang Chen1,2, Xiangkai Zhao1,2
1Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
International journal of environmental health research
|September 19, 2024
概括
焦炭炉排放 (COEs) 的暴露可能会增加血压. 基因变异PINK1,特别是rs3738136,与COEs相互作用,影响工人的心压和心压血压.
科学领域:
- 环境健康 环境健康
- 心血管遗传学 心血管遗传学
- 职业医学 职业医学是专业的.
背景情况:
- 焦炭炉排放 (COE) 含有与心血管损伤相关的多环芳 (PAH).
- 高血压患者表现出心肌线粒体敏感性.
- 遗传变异的影响,如PINK1中的单核酸多态 (SNPs),对COE诱导的异常血压的影响仍然不清楚.
研究的目的:
- 调查PINK1的遗传变异与暴露于COEs的工人的血压异常之间的关联.
- 为了确定PINK1 rs3738136的多态性是否会改变COEs对血压的影响.
主要方法:
- 使用SPSS 21.0.0对518名暴露于COE的工人的调查和统计分析.
- 概括的线性模型分析,以评估PINK1 rs3738136基因型与COE暴露在静缩血压 (SBP) 和静缩血压 (DBP) 之间的相互作用.
主要成果:
- 系统性血压 (SBP) 在高暴露组明显高于低暴露组.
- 在PINK1 rs3738136 (GA+AA) 基因型和COEs暴露之间发现了显著的相互作用,影响SBP (β = -6.537,p = 0.021) 和DBP (β = -4.811,p = 0.012).
结论:
- 这项研究首次确定了PINK1 rs3738136多态体在COE诱导的异常血压中的作用.
- 暴露于COEs的工人的异常血压是环境和遗传因素的结合结果.
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