脑脊髓液样本中的肠道病毒感染的临床和分子流行病学,2019-2023年
Daniel Pan1,2,3,4,5,6, Basant Mohamed7, Abhishek Gupta7
1Development Centre for Population Health, University of Leicester, Leicester, UK.
Journal of medical virology
|September 19, 2024
概括
在流行病限制期间,儿童非脊髓灰质炎肠道病毒中枢神经系统感染减少. 患有这些感染的儿童更有可能发烧,具有更高的生命体征和脑脊液异常.
科学领域:
- 病毒学 病毒学
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
背景情况:
- 非脊髓灰质炎肠道病毒 (NPEV) 是儿童中枢神经系统 (CNS) 感染的常见原因.
- 由于COVID-19和相关的限制,可能影响了各种传染病的发病率和表现.
研究的目的:
- 为了比较NPEV中枢神经系统感染的儿童在流行病限制之前和期间的临床特征和结果.
- 分析导致儿童中枢神经系统感染的NPEV的流行病学和遗传学特征.
主要方法:
- 从2019年3月到2023年4月,对被诊断患有NPEV中枢神经系统感染的儿童 (n=47) 和同时对照组 (n=129) 的回顾性比较分析.
- 收集的数据包括人口统计,临床症状,生命体征和脑脊液 (CSF) 分析.
- 对已识别的NPEV进行了遗传学分析.
主要成果:
- 在大流行期间,NPEV中枢神经系统感染的入院人数显著下降 (13%对比33%对照人群,p=0.003).
- 与对照组相比,患有NPEV中枢神经系统感染的儿童更年轻 (平均年龄41天),主要是男性 (59%),更容易发烧 (93%),呼吸和心率较高.
- 在NPEV病例中观察到高的CSF蛋白质,白细胞计数和较低的CSF葡萄糖. 遗传学分析表明,循环中的NPEVs的全球起源不同.
结论:
- 流行病限制与小儿NPEV中枢神经系统感染的减少有关.
- 儿童的NPEV中枢神经系统感染呈现出明显的临床和CSF发现,包括发烧和改变生命体征.
- 流通的NPEV显示出广泛的地理来源,突出显示了这些感染的全球性.
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