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Updated: Jun 12, 2025

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
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短链化抛因通过抑制α-KG/TET酶活性,损害了小鼠的精子生成过程

Ruiyang Meng1, Xingde Du1, Yu Fu1

  • 1College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China.

Environmental science & technology
|September 19, 2024
PubMed
概括

短链化 (SCCP) 通过降低α-KG水平,抑制DNA脱甲基酶TET酶,减少关键精子生成基因表达,影响精子质量,破坏男性生育能力.

关键词:
在SCCP中,SCCP是最重要的.这是一种TET酶.通过TGFβ路径.男性生殖毒性男性生殖毒性α-基质酸盐的使用情况

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Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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