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多重系统缩患者血清细胞因子水平的诊断值和相关性分析

Xueping Chen¹, Sihui Chen¹, Xiaohui Lai¹

¹Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in cellular neuroscience

|September 19, 2024

概括

瘤亡因子α (TNF-α) 在多重系统缩 (MSA) 患者中升高,可以帮助将其与健康个体区分开来. 介乐金-6 (IL-6) 和IL-8水平没有显著差异.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
生物标志物生物标志物

背景情况:

有限的研究存在于多重系统缩 (MSA) 中的外周血液细胞因子.
之前关于细胞因子与MSA症状相关的研究样本规模小,结果有争议.
没有先前的研究研究了MSA的血清细胞因子的诊断潜力.

研究的目的:

调查MSA患者血清细胞因子和临床症状之间的关联.
探索血清细胞因子的诊断价值,以区分MSA和健康对照.

主要方法:

在125名MSA患者和98名健康对照中测量了interleukin-6 (IL-6),interleukin-8 (IL-8) 和瘤亡因子α (TNF-α) 的血清水平.
在MSA患者中分析了血清细胞因子和临床变量之间的相关性.
用接收器运行特征 (ROC) 曲线来评估细胞因子对MSA的诊断价值.

主要成果:

与健康对照组相比,MSA患者的血清TNF-α水平显著更高 (AUC为0.768).
在MSA患者和对照人群中,IL-6和IL-8水平没有显著差异.
血清TNF-α与MSA患者的焦虑症状 (HAMA) 呈现出正相关性,独立于年龄和发病时的年龄.
血清IL-6与焦虑 (HAMA),抑郁 (HAMD) 和功能评分 (UMSARS I,UMSARS IV,IADL) 有关.

结论:

血清TNF-α是区分MSA患者和健康个体的潜在生物标志物.
血清TNF-α和IL-6水平升高可能与MSA中的焦虑症状有关.
虽然IL-6与各种临床方面相关,但只有TNF-α在MSA检测中显示出诊断效用.

关键词:

在IL-6的研究中,IL-6被认为是IL-6的基因.这就是TNF-α.协会分析协会分析分析它具有诊断价值的诊断价值.多个系统缩.

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