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酸通过减轻前额叶氧化应激和糖尿病老鼠模型中的亡来改善记忆功能障碍

Ramadhea Laila Afifa An-Nur Willya Saputri^1,2, Nur Arfian¹, Junaedy Yunus¹

¹Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.

Turkish journal of medical sciences

|September 19, 2024

概括

酸 (CGA) 可能通过增加额叶SOD1,SOD2和Bcl-2基因表达来增强糖尿病 (DM) 鼠的记忆力. 这项研究调查了CGA.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
生物化学生物化学

背景情况:

糖尿病与记忆功能障碍有关,特别是在额叶.
在DM中高血糖会诱导氧化应激和神经元亡.
酸 (CGA) 显示出潜在的神经保护作用.

研究的目的:

研究CGA对前额叶mRNA表达SOD1,SOD2,p53和Bcl-2在DM大鼠中的影响.
在DM大鼠模型中评估CGA对记忆功能的影响.

主要方法:

在Wistar大鼠中使用链毒素诱导了DM.
鼠被用不同剂量的CGA治疗.
使用莫里斯水迷宫 (MWM) 测试来评估记忆功能.
通过RT-PCR分析了SOD1,SOD2,p53和Bcl-2的额叶mRNA表达.

主要成果:

糖尿病大鼠表现出记忆障碍和减少SOD1和Bcl-2mRNA的表达.
在DM老鼠中,CGA治疗改善了记忆性能.
在DM大鼠的额叶中,CGA的使用显著增加了SOD1,SOD2和Bcl-2mRNA的表达.

结论:

酸可以改善DM老鼠的记忆功能.
这种改善的潜在媒介是前额叶SOD1,SOD2和Bcl-2mRNA表达的上调.

关键词:

基酸是一种基酸.莫里斯水迷宫是一个水迷宫.灭症 (apoptosis) 是一种死亡的过程.糖尿病糖尿病患者糖尿病患者氧化应激是一种氧化应激.

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