血清血管内皮生长因子在性结肠炎中具有诊断和预后意义
Musa Salmanoğlu1, İrfan Küçük2, Başak Çakir Güney1
1Department of Internal Medicine, Sultan 2. Abdülhamid Han Training and Research Hospital, Health Sciences University, İstanbul, Turkiye.
Turkish journal of medical sciences
|September 19, 2024
概括
血清血管内皮生长因子 (sVEGF) 和血清calprotectin (SCP) 在性结肠炎 (UC) 患者中升高. 这些生物标志物与疾病严重程度相关,可能有助于UC管理.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 性结肠炎 (UC) 与血清血管内皮生长因子 (sVEGF) 的升高有关.
- 关于血清蛋白 (SCP) 和sVEGF作为UC生物标志物的数据存在矛盾.
- 需要进一步调查sVEGF,SCP和UC表型之间的关系.
研究的目的:
- 评估UC患者的血清calprotectin (SCP) 和血清血管内皮生长因子 (sVEGF) 水平之间的关系.
- 评估SCP和sVEGF与UC疾病表型的关联.
- 确定SCP和sVEGF作为UC的辅助生物标记物的潜力.
主要方法:
- 预期病例控制研究,涉及60名UC患者和30名健康对照.
- 评估了临床,内镜和组织学活动指数 (MCS,MES,HAI).
- 与酶相关的免疫吸收试验 (ELISA) 用于测量sVEGF和SCP水平.
主要成果:
- 与对照组相比,UC患者的sVEGF和SCP水平的中位数显著更高 (分别为p=0.002和p<0.001).
- 在SCP和sVEGF水平之间观察到强烈的正相关性 (rho=0.819,p<0.001).
- sVEGF和SCP度与MCS,MES和HAI正相关,表明与疾病严重程度有关.
结论:
- 在UC患者中,sVEGF和SCP的水平升高.
- SCP和sVEGF水平与UC疾病活性和严重程度相关.
- sVEGF和SCP显示出作为管理UC的有价值的辅助生物标志物的潜力.
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