免疫抑制治疗的尖端:感染
Aybegüm Özşahin1, Tuba Ilgar2, Sudem Mahmutoğlu Çolak1
1Department of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Turkiye.
Turkish journal of medical sciences
|September 19, 2024
概括
用anakinra或tocilizumab治疗的严重COVID-19患者经历了感染,anakinra组的肺炎和血液感染率更高. 感染显著增加了30天死亡率,特别是在托西利祖马布组.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 严重的COVID-19治疗涉及抗生素,这可能导致感染等副作用.
- 评估接受这些免疫调节疗法的患者的感染风险和结果至关重要.
研究的目的:
- 评估用anakinra治疗的严重COVID-19患者感染的发生率和影响,与tocilizumab对比.
- 在这个患者队列中确定与感染发展相关的风险因素.
主要方法:
- 从两家医院对208名严重的COVID-19患者进行了回顾性分析.
- 收集有关感染发展,重症监护室 (ICU) 住院和30天死亡率的数据.
主要成果:
- 总体感染率为35.1%. 肺炎和血液感染率在阿纳金拉组更高 (p=0.043,p=0.010).
- 集中治疗室入院 (32.8倍的风险增加) 和住院时间是感染的重要风险因素.
- 在患有感染的患者中,30天死亡率明显高,特别是在托西利祖马布组 (p=0.001).
结论:
- 与tocilizumab相比,使用Anakinra与肺炎和血液感染率较高有关.
- 在严重的COVID-19患者中,感染显著增加了30天的死亡风险,特别是那些接受tocilizumab治疗的患者.
- 这项研究强调了在接受抗生素治疗重症COVID-19的患者中监测感染的重要性.
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