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一个恶性二人组:混合的髓状和状变异的乳头状甲状腺癌
Anwar Alshaakh Mohd Mari1, Joane Titus2, Vania Zayat3,4
1Internal Medicine, Hospital Corporation of America (HCA) University of Central Florida (UCF), Florida, USA.
Cureus
|September 19, 2024
概括
本案例研究详细介绍了一例罕见的甲状腺髓癌 (MTC) 和甲状腺 papillary 癌 (PTC) 混合病例,该病例发生在转移患者身上. 建议对MTC和PTC进行长期监测,因为它们的预后不同.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 骨髓性甲状腺癌 (MTC) 是罕见的,混合的MTC和乳头性甲状腺癌 (PTC) 更为罕见.
- MTC和PTC的共存引发了关于它们共同的起源或偶然发生的问题.
- 甲状腺恶性瘤需要仔细的诊断和管理,由于不同的预后.
研究的目的:
- 为了呈现一种转移性混合骨髓和乳头甲状腺癌的病例.
- 讨论这种罕见的混合甲状腺癌的临床表现,管理和病理生理学.
- 强调在类似情况下对MTC和PTC进行监测的重要性.
主要方法:
- 一个61岁的女性患有转移性混合MTC和PTC的病例报告.
- 精细针吸收 (FNA) 活检,全甲状腺切除术,部剖析和术后监测.
- 图像学研究 (超声波,CT) 和生物化学标记物 (素,甲状腺蛋白,CEA) 用于随访.
主要成果:
- 术后病理证实混合MTC (pT3b) 和卵泡变异PTC (pT1a) 具有阳性边缘和淋巴血管入侵.
- 术后升高的酸水平表明MTC存在,在部剖析后降低.
- 手术和放射治疗后的一年,成像显示没有复发,稳定色素和不可检测的甲状腺蛋白.
结论:
- 混合MTC和PTC是鲜为人知的,其潜在起源来自多能甲状腺细胞.
- 与PTC相比,MTC的过程更为激进,需要量身定制的监测.
- 患有混合MTC和PTC的患者应单独对两种癌症类型进行监测.
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