在整个生命周期内,大脑拓是执行功能的基础:专注于默认模式网络
A Menardi1,2, M Spoa3, A Vallesi1,2
1Department of Neuroscience, University of Padova, Padova, Italy.
默认模式网络 (DMN) 和前端平行网络 (FPN) 的休息状态功能连接性与整个寿命的执行功能 (EF) 有关. 该DMN显示较大的与年龄相关的变化,并可能是一个更敏感的标志物,整个生命的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 发育神经科学的发展神经科学.
背景情况:
- 执行职能 (EF) 的传统神经成像研究使用任务唤起的范式.
- 休息状态研究越来越多地用于检查大脑连接和认知表现的个体差异.
研究的目的:
- 通过静止状态功能磁共振成像 (fMRI) 来研究EFs在整个寿命中的神经支柱.
- 检查前对对联网络 (FPN) 和默认模式网络 (DMN) 的内在功能组织中的与年龄相关的变化.
主要方法:
- 利用了来自人类连接体项目寿命数据库的静止状态fMRI数据.
- 应用图形理论分析了500名健康个体 (10-100岁) 的FPN和DMN的功能连接组.
主要成果:
- FPN和DMN的拓性质与EF性能有关,但与控制任务 (图片命名) 无关.
- 默认模式网络 (DMN) 的拓组织对与年龄相关的变化比前端对象网络 (FPN) 更敏感.
结论:
- DMN比FPN更早成熟,更容易受到神经退行性变化的影响.
- 研究DMN的功能架构与整个生命周期的高阶认知相关的研究可能会提供重要的见解,特别是在基于任务的fMRI具有挑战性的人群中.
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