干燥的根改善了肠道功能,有利于肠道微生物的食物链,并增加了便和循环短链脂肪酸在2型糖尿病风险的受试者
Marie-Luise Puhlmann1,2, Roosa Jokela3, Katja Catharina Wilhelmina van Dongen1,4
1Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Gut microbiome (Cambridge, England)
|September 19, 2024
概括
干燥的根改善了肠道规律性,并调节了2型糖尿病风险的人的肠道细菌. 这种干预也增强了葡萄糖平衡和有益的肠道代谢物,如丁酸盐.
科学领域:
- 微生物学 微生物学
- 营养 营养 营养 营养 营养
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病风险与肠道微生物群变化和葡萄糖代谢受损有关.
- 饮食干预对于管理代谢健康和预防2型糖尿病至关重要.
研究的目的:
- 为了研究干燥的根对肠道功能,肠道微生物群和葡萄糖平衡在2型糖尿病风险的个体的影响.
主要方法:
- 一个随机的,安慰剂控制的试验,涉及55名2型糖尿病风险的参与者.
- 评估肠道功能,肠道微生物组成,短链脂肪酸水平和葡萄糖参数 (禁食葡萄糖,HOMA-ir,血糖变化系数).
主要成果:
- 干燥的根显著增加了便的软度和频率.
- 肠道微生物群的组成被调节,增加了Anaerostipes和Bifidobacterium spp.的水平.
- 便和循环中的酸盐,酸和丁酸盐水平增加.
- 血糖变化系数下降,在特定亚组中,禁食葡萄糖和HOMA-ir得到改善.
结论:
- 干燥根的摄入对肠道功能和肠道微生物群组成产生积极影响.
- 这种干预措施促进有益的肠道细菌,并增加丁酸盐的生产.
- 香草根显示出改善血糖控制的潜力,并为预防2型糖尿病进行进一步的研究.
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