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Updated: Jun 12, 2025

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确定人乳寡糖的代谢命运:它可能比你想象的更复杂?

Peter Philip James Jackson¹, Anisha Wijeyesekera¹, Robert Adrian Rastall¹

¹Department of Food and Nutritional Sciences, University of Reading, Reading, UK.

Gut microbiome (Cambridge, England)

|September 19, 2024

概括

人母乳寡糖 (HMO) 是母乳中的复杂糖,有利于婴儿的肠道微生物. 本次审查审查了婴儿配方中特定的HMO,2'-糖乳糖 (2'FL) 和乳糖-N-新糖 (LNnT) 的有限证据.

科学领域:

人类牛奶寡糖 (HMO) 是复杂的碳水化合物,在婴儿营养和发育中具有重要的生物学作用.

背景情况:

在母乳中大量存在HMO,选择性地养有益的肠道细菌并抑制病原体.
婴儿配方奶粉通常缺乏母乳中发现的HMO的多样性,通常只含有2种extquotesingle-fucosyllactose (2种extquotesingleFL) 和lacto-N-neotetraose (LNnT).
这些特定的HMO在配方中的好处,特别是关于呼吸道感染和微生物群调节的好处,需要进一步研究.

研究的目的:

审查HMO的概念和代谢命运.
总结现有的HMO体外和体内临床数据,重点关注2个单独的FL和LNnT.
评估当前对单一FL和LNnT对婴儿健康和微生物群的影响的理解.

主要方法:

关于HMO,2 extquotesingleFL和LNnT的体外和体内研究的文献综述.
分析与HMO消费相关的代谢途径和临床数据.
专注于有关呼吸道感染和婴儿肠道微生物群组成的证据.

主要成果:

人类牛奶寡糖 (HMOs) 是结构多样化的甘氨酸,对婴儿肠道健康至关重要.
目前的婴儿配方奶粉含有有限的HMO (2 extquotesingleFL, LNnT),对其有效性的体内数据不足.
对于减少呼吸道感染和改变微生物群的证据很少.

结论:

需要进一步的研究来验证婴儿配方奶粉中特定的HMO如2 extquotesingleFL和LNnT的益处.
了解HMO代谢和体内效应对于优化母乳以外的婴儿营养至关重要.
该审查强调了关于基于配方奶粉的HMO对婴儿健康结果的影响的知识差距.

关键词:

这种细菌是Bifidobacterium.人类牛奶中的寡糖 (HMO)交叉养交叉养是什么我们的肠道微生物群.婴儿配方奶粉的使用方法婴儿婴儿婴儿婴儿婴儿

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