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婴儿肠道微生物组合和新陈代谢在暴露于草甘和Roundup和/或使用SHIME技术的基因基配方后的变化

Robin Mesnage¹, Marta Calatayud², Cindy Duysburgh²

¹Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy's Hospital, London, SE1 9RT, UK.

Gut microbiome (Cambridge, England)

|September 19, 2024

概括

暴露于甘酸盐和圆环剂改变了婴儿肠道细菌,增加了发酵和酸化. 一种益生菌配方有助于逆转对肠道微生物群组成和功能的一些有害影响.

科学领域:

微生物学微生物学
毒理学毒理学毒理学
人类肠道微生物组研究研究

背景情况:

对草甘毒理学进行了广泛的研究,但其对人类肠道微生物群的影响在很大程度上是未知的.
了解除草剂对婴儿肠道微生物群的影响对于评估潜在的健康风险至关重要.

研究的目的:

调查草甘和基于草甘的草药 Roundup 对婴儿肠道微生物群的影响.
评估益生菌配方对抗这些影响的潜力.

主要方法:

利用人类肠道微生物生态系统模拟器 (SHIME) 技术进行婴儿肠道微生物群培养.
暴露在100mg/L草甘和同等度的Roundup的培养物中.
分析了微生物环境的变化,代谢物生产 (乳酸盐,酸盐,SCFA,氨) 和细菌组成 (qPCR,16SrRNA).

主要成果:

草甘和Roundup都增加了发酵,导致微生物环境的酸化.
轮暴露增加了氨产量,表明蛋白质分解活性升高.
观察到短链脂肪酸 (SCFA) 形状的显著变化和长链多不和脂肪酸的增加.
细菌组成分析表明,由于微环境酸化,乳酸菌的生长受到刺激.
与MegaSporeBiotic益生菌的同时治疗部分逆转了SCFA水平的变化.

结论:

草甘和轮剂显著影响人类肠道微生物群,改变其代谢活动和组成.
观察到的酸性化和SCFA生产的变化表明肠道健康的潜在破坏.
基于子的益生菌可能提供一种策略,以减轻草甘基除草剂对肠道微生物群的一些不良影响.

关键词:

这里是SHIMEIME.草甘是一种草甘.我们的肠道微生物群.代谢生物组的代谢生物组杀虫剂杀虫剂杀虫剂益生菌是一种益生菌.

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