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与抗IgLON5自身免疫性疾病相关的肌心炎在免疫检查点抑制剂治疗后发生

James F Howick V¹, Jasraj Singh¹, Petar Saric²

¹Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

JACC. Case reports

|September 19, 2024

概括

心肌炎是心肌的炎症,通常是由病毒引起的. 这项研究报告了第一例心肌炎发生在患有抗IgLON5疾病的患者身上,这是一种罕见的自身免疫性疾病.

科学领域:

心脏病学心脏病学
神经学神经学
免疫学免疫学免疫学

背景情况:

心肌炎是心肌的炎症,通常是由病毒感染引起的.
系统性自身免疫性疾病也可能导致心肌炎性损伤,尽管不那么频繁.
含有1 (IgLON1) 疾病的抗免疫球蛋白类域是一种罕见的自身免疫神经系统疾病.

研究的目的:

报告第一个被诊断为抗IgLON5疾病的患者心肌炎的记录病例.
为了突出抗IgLON5疾病和心脏炎症之间的潜在关联.
扩大对抗IgLON5疾病的临床表现的理解.

主要方法:

案例报告的呈现方式.
对临床病史,诊断工作和患者的治疗进行审查.
分析关于心肌炎和抗IgLON5疾病的现有文献.

主要成果:

患者出现了暗示心肌炎的症状.
在患有抗IgLON5疾病的患者中证实了心肌炎.
这代表了第一个报告的例子,将这两个条件联系在一起.

结论:

肌心炎可能是抗IgLON5疾病的表现.
这些发现表明,在抗IgLON5疾病的背景下,自身免疫过程在心脏损伤中的潜在作用.
需要进一步的研究来探索心脏参与抗IgLON5疾病的患病率和机制.

关键词:

在ICI中毒性毒性.抗IgLON5疾病的疾病.自己免疫性心肌炎.免疫检查点抑制剂疗法免疫检查点抑制剂疗法炎症性心肌病性心脏病发作肌性心肌炎是一种心肌炎.新的呈现方式.

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