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相关概念视频

Types of RNA01:23

Types of RNA

63.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
63.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Bacterial RNA Polymerase00:43

Bacterial RNA Polymerase

29.4K
Unlike eukaryotes, bacteria use a single RNA Polymerase (RNAP) to transcribe all genes. The different subunits of bacterial RNAPhave distinct functions. The multisubunit structure of the bacterial RNAP helps the enzyme to maintain catalytic function, facilitate assembly, interact with DNA and RNA, and self-regulate its activity.
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
29.4K
CRISPR and crRNAs02:53

CRISPR and crRNAs

16.9K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
16.9K
Prokaryotic Transcriptional Activators and Repressors01:58

Prokaryotic Transcriptional Activators and Repressors

20.8K
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
20.8K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.6K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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相关实验视频

Updated: Jun 12, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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在细菌感染中,宿主长非编码RNA.

Yong Cheng1,2, Yurong Liang2,3, Xuejuan Tan1,2

  • 1Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, United States.

Frontiers in immunology
|September 19, 2024
PubMed
概括

长非编码RNAs (lncRNAs) 是细菌感染的关键调节者,影响宿主防御和病原体生存. 了解这些宿主 lncRNA 提供了针对细菌疾病的新临床策略的潜力.

关键词:
细菌感染 细菌感染宿主细胞是宿主细胞的细胞.主体-病原体相互作用免疫力是一种免疫力.长非编码RNAs的编码.

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A Non-Coding Small RNA MicC Contributes to Virulence in Outer Membrane Proteins in Salmonella Enteritidis
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A Non-Coding Small RNA MicC Contributes to Virulence in Outer Membrane Proteins in Salmonella Enteritidis

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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相关实验视频

Last Updated: Jun 12, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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A Non-Coding Small RNA MicC Contributes to Virulence in Outer Membrane Proteins in Salmonella Enteritidis
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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科学领域:

  • 分子生物学分子生物学
  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学

背景情况:

  • 细菌感染对全球健康构成重大挑战.
  • 宿主-病原体相互作用是传染病结果的关键.
  • 非编码RNAs (ncRNAs),特别是长非编码RNAs (lncRNAs),是这些相互作用的新兴调节者.

研究的目的:

  • 审查宿主 lncRNAs 在细菌感染中的多方面的作用.
  • 阐明 lncRNAs 如何调节宿主-病原体相互作用.
  • 突出 lncRNAs 在宿主防御和细菌病原性中的双重功能.

主要方法:

  • 关于宿主 lncRNA 和细菌感染的最新研究的文献综述.
  • 对基因表达,细胞过程和免疫反应中的lncRNA调节机制的分析.
  • 综合了关于 lncRNAs 对细菌入侵,复制和传播的影响的发现.

主要成果:

  • 宿主 lncRNAs 作为对抗细菌病原体的防御机制.
  • 某些宿主 lncRNAs 可以促进细菌的生存,复制和蓄水池的形成.
  • lncRNAs在细胞因子和化学因子生产中表现出不同的调节作用.

结论:

  • 宿主 lncRNA 在细菌感染中起着复杂的双重作用.
  • 对宿主 lncRNAs 的进一步研究对于了解传染病至关重要.
  • 利用 lncRNA 调节潜力可能会为治疗细菌感染带来新的临床应用.