孕鼠中的牙周炎和糖尿病:母胎结局
Samuel Santos Souza1, Larissa Lopes Cruz1,2, Amanda Munnick Alves-Reis1
1Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso, 78605-091, Barra do Garças, Mato Grosso State, Brazil.
Heliyon
|September 19, 2024
概括
孕产妇糖尿病和牙周炎显著损害怀孕结果和新生儿发育,增加异常. 保持口腔健康对于后代的健康至关重要,尤其是糖尿病母亲.
科学领域:
- 生殖生物学和内分泌学.
- 口腔健康和全身性疾病的相互作用
- 发展性毒理学 发展性毒理学
背景情况:
- 牙周炎和糖尿病是普遍存在的慢性疾病.
- 这两种情况都独立地与不良妊娠结果有关.
- 牙周炎和糖尿病对母亲和胎儿健康的综合影响需要进一步研究.
研究的目的:
- 为了研究牙周炎和糖尿病对大鼠怀孕的协同作用.
- 评估对母亲生理参数和生殖能力的影响.
- 评估对新生儿发育和异常发生率的后果.
主要方法:
- 在雌性Wistar大鼠中使用链毒素诱导糖尿病.
- 牙周炎是通过怀孕期间的带放置引起的.
- 评估母亲的体重,葡萄糖耐受性,血液参数和气泡骨损失.
- 评估生殖结果和新生儿参数,包括体重和异常.
主要成果:
- 糖尿病和牙周炎的结合加剧了膜骨损失和母亲的全身炎症.
- 观察到胚胎损失增加和对母体代谢标志物的不良影响.
- 来自联合条件母亲的新生儿出生时体重更高,胎盘体重更高,骨和内脏异常明显更多.
结论:
- 孕妇糖尿病和牙周炎的同时发生会对怀孕和胎儿发育产生不利影响.
- 这些发现强调了孕妇口腔健康在减轻怀孕期间糖尿病相关风险方面的关键作用.
- 针对口腔健康的干预策略可能会改善糖尿病母亲及其后代的怀孕结果.
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